The sexual abuse scandal in the Catholic Church captured headlines and mobilized public outrage in January 2002. But much of the commentary that immediately followed was reductionistic, focusing on single "causes" of clerical abuse such as mandatory celibacy, homosexuality, sexual repressiveness or sexual permissiveness, anti-Catholicism, and a decadent secular culture. _Predatory Priests, Silenced Victims: The Sexual Abuse Crisis and the Catholic Church_, a collection of groundbreaking articles edited by Mary Gail Frawley-O'Dea and Virginia Goldner, eschews such one-size-fits-all theorizing. In (...) its place, the abuse situation is explored in all its troubling complexity, as contributors take into account the experiences, respectively, of the victim/survivor, the abuser/perpetrator, and the bystander. Setting polemics to the side, _Predatory Priests, Silenced Victims_ provides a sober and sobering analysis of the interlacing historical, doctrinal, and psychological issues that came together in the sexual abuse scandal. It is mandatory reading for all who seek thoughtful, informed commentary on a crisis long in the making and yet to be resolved. (shrink)

This paper advances the thesis that sensory concepts have as a semantic component the first-person indexical. It is argued that the private nature of our access to our own sensations forces, in our talking about them, an indexical reference to the inner states of the speaker in lieu of publicly accessible properties by which reference is usually fixed. Indexicals, such as ‘here’, can be understood despite ignorance of their referent. Such is the case with sensory terms. Furthermore, the thesis that (...) sensory terms are indexical has considerable explanatory power. I give two examples: firstly, I argue that clashes of intuition over Block's ‘inverted spectrum’ thought experiment can be explained by appeal to semantic properties of indexicals. Secondly, I argue that multiple realisability intuitions can be shown to be consistent with the view that sensations are type-identical with brain states. (shrink)

The representational theory of phenomenal experience is often stated in terms of a supervenience thesis: Byrne recently characterises it as the thesis that “there can be no difference in phenomenal character without a difference in content”, while according to Tye, “[a]t a minimum, the thesis is one of supervenience: necessarily, experiences that are alike in their representational contents are alike in their phenomenal character.” Consequently, much of the debate over whether representationalism is true centres on purported counter-examples – that is (...) to say, purported failures of supervenience. The refutation of putative counter-examples has been, it seems to me, by and large successful. But there is a certain class of these for which the representationalist response has been something less than completely convincing. These are the cross-modality cases. I will explain what I mean, and then argue that the response in question is not only unconvincing but actually undermines the representationalist position. (shrink)

Perceptual constancy, often defined as the perception of stable features under changing conditions, goes hand in hand with variation in how things look. A white wall in the orange afternoon sun still looks white, though its whiteness looks different compared with the same wall in the noon sun. Historically, this variation has often been explained in terms of our experience of “merely sensory” or subjective properties – an approach at odds with the fact that the variation does track objective features (...) of the perceptual situation, such as illumination. One approach, becoming more common, is to account for the variation in terms of further “dimensions” to perceptual experience. Especially in colour perception, this is a natural thought to have but the idea is often left vague. In this paper I argue that the “dimensional” strategy has problems of its own, but is useful in drawing out some interesting complications in the way perceptual experience is structured. Specifically, the structure of “constancy spaces” brings out the different ways in which there is stability and instability in the experience of constancy, without the need for novel or merely subjective features. Instability arises in a contingent structural feature of perceptual experience. (shrink)

I defend a solution to a long-standing problem with perceptual appearances, brought about by the phenomenon of perceptual constancy. The problem is that in conditions which are non-ideal, yet within the range that perceptual constancy works, we see things veridically despite an “appearance” which is traditionally taken to be non-veridical. For example, a tilted coin is often taken to have an “elliptical appearance”, shadowed surfaces a “darker appearance”. These appearances are puzzling for a number of reasons. I defend and elaborate (...) on an approach taken by Sean Kelly, and earlier by the art historian E.H. Gombrich, according to which we can be tricked by our ability to bring about a kind of Gesltalt shift between different possible perceptual interpretations of a scene. (shrink)

Representationalist theories of sensory experience are often thought to be vulnerable to the existence of apparently non-representational differences between experiences in different sensory modalities. Seeing and hearing seem to differ in their qualia, quite apart from what they represent. The origin of this idea is perhaps Grice’s argument, in “Some Remarks on the Senses,” that the senses are distinguished by “introspectible character.” In this chapter I take the Representationalist side by putting forward an account of sense modalities which is consistent (...) with that view and yet pays due regard to the intuition behind Grice’s argument. Employing J.J. Gibson’s distinction between exploratory and performatory behaviour, I point to a proprioceptive element in perceptual experience, and identify this as crucial in any account of what makes a particular way of perceiving a sense modality. (shrink)

If we assume that the operation of each sense modality constitutes a different experience – a visual experience, an auditory experience, etc – we are faced with the problem of how those distinct experiences come together to form a unified perceptual encounter with the world. Michael Tye has recently argued that the best way to get around this problem is to deny altogether that there are such things as purely visual (and so forth) experiences. Here I aim to show not (...) simply that Tye’s proposed solution fails, but that its failure is highly instructive because it allows us to see that the transparency thesis, which lies at the heart of the case against qualia, and of most representationalist theories of experience, is more problematic than is often supposed. (shrink)

ABSTRACT This paper suggests a much more serious purpose for an education in music-making than play or pleasure or even the training of professional musicians. It presents and explicates a possible connection between musical performance training and the development of practical wisdom. Music in performance constitutes in effect a form of virtuous conduct, where one learns through doing and thereafter comes to love and to be capable of wise practical judgement. Excellence in this field requires the exercise of a species (...) of reasoning and judgement analogous to Aristotelian practical wisdom, and develops the distinctive qualities of character and vision of the practically wise person. (shrink)

In North America, across the political spectrum, we have a strong tendency to reduce religion to nothing more than a tool to promote our own socio-political views. This is a natural consequence of our hyper-polarized culture and our impoverished view of “religion.” It is also, however, a problem—particularly for those inspired by the call to renewal through an integration of the quest for social justice and the pursuit of the spiritual life. By focusing on the value of participating in religious (...) liturgy, I show how a renewed respect for religion can help the proponents of social justice fulfil some of the foundational desires of the original movement and, thereby, to bring to fruition some of its dormant promise. This includes, in particular, the desire for social harmony and the desire to pay greater attention to our concrete reality. (shrink)

School shootings publicized worldwide inevitably awaken the debate about contemporary communication media and violence. It is often conjectured that regular exposure of young people to countless acts of aggression in contemporary popular media leads them to become more aggressive and, in some cases, to commit violent crimes. But is this claim valid? Media guru Marshall McLuhan argues that it is not so much the content of such media that incites aggressive actions as the sociostructural conditions they bring into being. In (...) this article, Jane O'Dea draws on the cultural context of postmodernity and on Jean Baudrillard's thought to explore and critically assess the validity of the linkage McLuhan proposes, identifying the kinds of questions, inquiries, and educational implications it potentially raises. (shrink)

Higher-order theories of consciousness, such as those of Armstrong, Rosenthal and Lycan, typically distinguish sharply between consciousness and phenomenal character, or qualia. The higher-order states posited by these theories are intended only as explanations of consciousness, and not of qualia. In this paper I argue that the positing of higher-order perceptions may help to explain qualia. If we are realists about qualia, conceived as those intrinsic properties of our experience of which we are introspectibly aware, then higher-order perception might have (...) an explanatory role as the means by which we are aware of these properties. This would also allow us to treat qualia as the inner appearances resulting from inner perceptions, and therefore to treat them as intentional objects. (shrink)

Uses a virtue-based approach to the ethical dimension and to the roles of virtuosity and historical authenticity in musical performance.

Our popular conception of integrity brings to mind uncompromising figures like Socrates or Sir Thomas More whose steadfast stands on matters of principle we accept and admire. The paper considers the implications of this for two committed feminists, both of whom are teachers. Their pedagogical philosophies are sufficiently different to lead one to charge the other with selling out her feminist principles. But is this a fair assessment? Is there room for compromise within the complex notion of integrity? How might (...) feminist teachers rework the concept to do justice to the complexities involved? (shrink)

Entry for the Companion to Philosophy in Australia and New Zealand.

Small family businesses have generally been shown to exhibit significant concern for social responsibility, especially at the community level. Despite the reported heterogeneity of family firms in their preferences for and participation in social responsibility, the drivers of such differences are not agreed upon in the literature. We draw from enlightened self-interest and social capital theories by exploring their complementary and competing implications for the effect of duration and community satisfaction on participation in community-oriented social responsibility. Additionally, drawing on the (...) association between gender and self-construal and evidence that gender shapes helping and giving behaviors, we assess the moderating role of the gender of the firm manager in these relationships. We test our hypotheses on a sample of 279 family businesses and find support that gender moderates the relationship between community duration and satisfaction and measures of CSR. (shrink)

For philosophers familiar with the traditional interpretation of Simone de Beauvoir as a literary writer and philosophical follower of Jean-Paul Sartre, Beauvoir’s 1926-27 student diary is a revelation. Inviting an exploration of Beauvoir’s early philosophy foreclosed by the traditional interpretation, the student diary reveals Beauvoir’s early dedication to becoming a philosopher and her early formulation of philosophical problems and positions usually attributed to Sartre’s influence, such as the central problem of “the opposition of self and other,” years before she first (...) met Sartre in 1929.… Reading the student diary within a larger historical context, we discover that it reflects Beauvoir’s experience as one of the first generation of French women to gain full access to the academic world of philosophy, an experience that problematizes her identity as a woman. The diary shows Beauvoir struggling to accommodate herself to the male world of philosophy while striving to make philosophy her own. For Beauvoir this means following Henri Bergson in rejecting a philosophy that engages only the abstract intelligence. Defining her own unique literary philosophical methodology, Beauvoir vows to create a philosophy that is able, like literature, to encompass emotion as well as reason. This creative process begins in her diary where Beauvoir describes the concrete realities of her own lived experience. Searching for a sense of self in the “nothingness of everything human,” Beauvoir grapples with the existential problem of despair and the temptations of bad faith. Celebrating her newly found freedom and academic achievements, Beauvoir still struggles with the masochistic asceticism of her Catholic upbringing and longs for love, fearing a solitary future bereft of the comforts of woman’s traditional role. Beauvoir’s student diary thus allows us to trace the development of her early philosophy within the context of her life, while providing as well an intimate view of an academic world in transformation…. When the diary opens, with an entry dated August 6, 1926 Beauvoir is grappling with a central problem of her early life and philosophy, the conflicting moral obligations to self and others. Recounting a pilgrimage to Lourdes with an aunt, Beauvoir recalls feeling “ashamed” when faced with the physical suffering of the invalids: “[O]nly a life which was a complete gift of oneself, a total self-abnegation seemed possible to me.” But then, anticipating her critique of self-abnegation in The Second Sex, Beauvoir rejects it, describing the “absolute gift” as “moral suicide.” She vows, instead, to achieve an “equilibrium” between the duty to self and the duty to others. In the August 12, 1926 diary entry, Beauvoir frames the problem in metaphysical terms, referring to one part of herself “made to be given away,” and another “made to be kept and cultivated.” Later, in the November 5, 1926 entry, Beauvoir returns to the problem, writing that she split her “existence into two parts”: one part “for myself” and the other part “for others,” that is “the bonds that unite me with all beings.” Beauvoir’s 1926 description of existence “for myself” and “for others” lays the ground for her later philosophical work on the problem of the Other, as in her 1943 metaphysical novel, She Came to Stay, where the main female protagonist struggles to reclaim an existence for herself instead of existing solely for others, and in The Second Sex (1949) where Beauvoir argues that women are forced to assume themselves not as they exist for themselves but solely as they exist for men, thus as the absolute Other. During the course of the 1926 diary, Beauvoir’s efforts to reconcile these two “parts” of her existence are complicated by various influences, including her reading of Henri Bergson, the leading French philosopher of the early twentieth century. Beauvoir quotes at length in her 1926 diary from Bergson’s Essay on the immediate data of consciousness, which she describes, on August 16, as “a great intellectual rapture.” This diary entry may surprise those who remember the reference to Bergson in Beauvoir’s Memoirs: “I would not have been at all pleased if someone had prophesized that I would become a kind of Bergson; I didn’t want to speak with that abstract voice which, whenever I heard it, failed to move me” (MJFR 288). In this case as in so many others, Beauvoir’s diaries present a very different picture. In the August 16 diary entry, Beauvoir is critical of Bergson’s “impersonal” philosophical voice. But she lauds his methodological “appeal to intuition," which brings philosophy in contact with the « palpable reality » of life, as more characteristic of literature than philosophy. Beauvoir quotes Bergson’s celebration of the « bold novelist » able to tear aside « the cleverly woven web of our conventional self, » and reveal the « fundamental absurdity » of impressions underneath. « Nobody has better than he … defined the art of the modern novelist » Beauvoir writes, suggesting Bergson’s influence on Beauvoir’s developing literary philosophical method. Beauvoir writes, in the August 16 entry, that she is “thrilled” by Bergson’s “analysis of the two aspects of the self,” the authentic inner self and the external social self. For Bergson, unlike Beauvoir who is concerned with serving others as well as the self, our responsibility is wholly to the self and its freedom, which we discover only by breaking through the superficial “crust” of the social self. If his ethic of individual freedom complicated Beauvoir’s search for an ethical “equilibrium,” Bergson’s methodological turn to intuition and rejection of philosophy’s sole reliance on reason might have appealed to a young women trying to enter the male world of philosophy and make it her own…. (shrink)

The impact of gender on assessments of leadership performance and leadership potential was examined through two clusters of leadership behaviors, one set related to traditional constructions of leadership labeled directing others and another associated with contemporary constructions of leadership labeled engaging others. Based on data collected from a sample of 91 senior leaders in one US financial services organization over a 3-year period prior to Covid-19, the results showed a negative relationship between directing others behaviors and leadership potential ratings for (...) females and a positive relationship between these variables for males. A negative relationship between engaging others behaviors and performance assessments was also found for females. This study highlights the continuing bias in leadership assessments of women and explores the contradictions between the perception and the reality of women's leadership. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

In this article we assess the extant literature on women’s careers appearing in selected career, management and psychology journals from 1990 to the present to determine what is currently known about the state of women’s careers at the dawn of the 21st century. Based on this review, we identify four patterns that cumulatively contribute to the current state of the literature on women’s careers: women’s careers are embedded in women’s larger-life contexts, families and careers are central to women’s lives, women’s (...) career paths reflect a wide range and variety of patterns, and human and social capital are critical factors for women’s careers. We also identify paradoxes that highlight the disconnection between organizational practice and scholarly research associated with each of the identified patterns. Our overall conclusion is that male-defined constructions of work and career success continue to dominate organizational research and practice.We provide direction for a research agenda on women’s careers that addresses the development of integrative career theories relevant for women’s contemporary lives in hopes of providing fresh avenues for conceptualizing career success for women. Propositions are identified for more strongly connecting career scholarship to organizational practice in support of women’s continued career advancement. (shrink)

In this article we assess the extant literature on women’s careers appearing in selected career, management and psychology journals from 1990 to the present to determine what is currently known about the state of women’s careers at the dawn of the 21st century. Based on this review, we identify four patterns that cumulatively contribute to the current state of the literature on women’s careers: women’s careers are embedded in women’s larger-life contexts, families and careers are central to women’s lives, women’s (...) career paths reflect a wide range and variety of patterns, and human and social capital are critical factors for women’s careers. We also identify paradoxes that highlight the disconnection between organizational practice and scholarly research associated with each of the identified patterns. Our overall conclusion is that male-defined constructions of work and career success continue to dominate organizational research and practice. We provide direction for a research agenda on women’s careers that addresses the development of integrative career theories relevant for women’s contemporary lives in hopes of providing fresh avenues for conceptualizing career success for women. Propositions are identified for more strongly connecting career scholarship to organizational practice in support of women’s continued career advancement. (shrink)

Data from 590 college graduates are used to assess the relationship between family employment status and gender role attitudes for a predominately European American sample. The women in this study are employed full time, part time, or are full-time homemakers, and all report being married to men employed full time. The men in the study are all employed full time and report having wives who are employed full time, part time, or are full-time homemakers. Controlling for the effects of selected (...) background factors, full-time employed women are the most supportive of nontraditional family gender roles, followed by part-time employed women. The attitudes of homemakers are more similar to those of the men. Few significant differences exist when comparing the men with full-time employed wives, those with part-time employed wives, and men married to homemakers. The findings suggest an important link between work experiences, lifestyle choices, and gender role attitudes, particularly for women. (shrink)

Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age‐associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we (...) emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets. Copyright Line: © 2015 The Authors BioEssays Published by Wiley‐VCH Verlag GmbH & Co. KGaA. (shrink)

This paper focuses on ethics in community-based participatory research (CBPR) from inception to post-publication. Central to CBPR is a collaborative, partnership approach that recognises the strengths of partners and engages their distinctive voice and knowledge in the research process. While the ethical complexities that arise in the course of research practice in CBPR can transcend individual projects, they are also grounded in the particularity of the project, community, and research partners. This paper reflects on the experiences of two participatory social (...) policy research projects on housing in Ireland, conducted over the past three years. These projects involved collaborating with older people living in rural areas nationwide and with residents of small communities on offshore islands. The paper explores the ethics of engagement (regarding methods of involvement and access), and the ethics of representation (incorporating the depiction and sharing of research findings) and argues that researchers must pay attention to the specificity of each project and be alive to generating an organic research ethics in how research is set up, conducted, represented, and disseminated. In so doing, we can better foster agency and authenticity in the relationships developed throughout research processes and reflect on and meet shared values and responsibilities. (shrink)

This article discusses the place of sedation in the care of the terminally ill, as used in the practice of palliative care using case studies, clinical pragmatism forms the theoretical framework from which to elucidate the varying part that sedation plays in the overall management of a person facing the end of life. We contend that when used appropriately, sedation is an ethical and legitimate intervention that enhances comfort at the end of life and ought not sedate the person onto (...) “oblivion”. (shrink)

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

This study examined whether holding a status-consistent or status-inconsistent position affected the work satisfaction of college-educated, white-collar employees. The status-consistent group contained 128 women and 118 men. The status-inconsistent group was composed of 89 women and 102 men. Our results indicated that workers in occupations in which the majority of workers are the same gender had significantly higher levels of work satisfaction than those in status-inconsistent occupations. However, subsequent analyses revealed that men and women employed in occupations in which the (...) majority of workers are men had higher levels of work satisfaction than those employed in women-dominated occupations. These findings held when controlling for other work-satisfaction factors, such as individual earnings, hours worked per week, and length of time employed. We suggest that the effect of status consistency on work satisfaction is mediated by the cultural value attached to the occupations men dominate. (shrink)

It has long been known that Jean-Baptiste Du Bos exercised a considerable influence on Hume’s essays and, in particular, on the ‘Of the Standard of Taste’ and ‘Of Tragedy’. It has also been noted that some passages in the Treatise bear marks of Du Bos’ influence. In this essay, we identify many more passages in the Treatise that bear unmistakable signs of Du Bos’ influence. We demonstrate that Du Bos certainly had a significant impact on Hume as he wrote the (...) Treatise. We go on to argue that Hume’s views on morality are an extension to the moral realm of Du Bos’ views on beauty and criticism. Du Bos may also have influenced Hume’s distinction between ideas and impressions. (shrink)

Background: The right of children to have their voice heard has been accepted by researchers, and there are increasing numbers of qualitative health studies involving children. The ethical and methodological issues of including children in research have caused worldwide concerns, and many researchers have published articles sharing their own experiences. Objectives: To systematically review and synthesise experts’ opinions and experiences about ethical and methodological issues of including children in research, as well as related solution strategies. Research design: The research design (...) was a systematic review of opinion-based evidence, based on the guidelines by Joanna Briggs Institute. Methods: A search of five computerised databases has been conducted in April 2014 and 2271 articles were found. After screening the titles, abstracts, full texts and appraising the quality, 30 articles were finally included in the review. A meta-aggregative approach was applied in the data analysis and synthesis process. Ethical considerations: Ethical approval is not needed as it is a systematic review of published literature. Results: Six themes were identified, including evaluating potential risks and benefits, gaining access, obtaining informed consent/assent, protecting confidentiality and privacy, building rapport and collecting rich data. The similarities and differences between research involving children and that involving adults were indicated. Conclusion: All potential incentives should be justified when designing the study. Further studies need to research how to evaluate individual capacity of children and how to balance protecting children’s right to participate and their interests in the research. Cultural differences related to researching children in different regions should also be studied. (shrink)

Research has shown that paternal involvement positively impacts on child health and development. We aimed to develop a conceptual model of dimensions of fatherhood, identify and categorise methods used for linking fathers with their children in administrative data, and map these methods onto the dimensions of fatherhood. We carried out a systematic scoping review to create a conceptual framework of paternal involvement and identify studies exploring the impact of paternal exposures on child health and development outcomes using administrative data. We (...) identified four methods that have been used globally to link fathers and children in administrative data based on family or household identifiers using address data, identifiable information about the father on the child's birth registration, health claims data, and Personal Identification Numbers. We did not identify direct measures of paternal involvement but mapping linkage methods to the framework highlighted possible proxies. The addition of paternal National Health Service numbers to birth notifications presents a way forward in the advancement of fatherhood research using administrative data sources. (shrink)

This book is a rich blend of analyses by leading experts from various cultures and disciplines. A compact introduction to a complex field, it illustrates biotechnology's profound impact upon the environment and society. Moreover, it underscores the vital relevance of cultural values. This book empowers readers to more critically assess biotechnology's value and effectiveness within both specific cultural and global contexts.

Disturbances of consciousness, including fluctuations in attention and awareness, are a common and clinically important symptom in dementia with Lewy bodies. In the present study we investigate potential mechanisms of such disturbances of consciousness in a clinicopathological study evaluating specific components of the cholinergic system. [3H]Epibatidine binding to the high-affinity nicotinic receptor in the temporal cortex differentiated DLB cases with and without DOC, being 62–66% higher in those with DOC. The were no differences between DLB patients with or without DOC (...) in 125I-labeled α-bungaratoxin binding to the low-affinity nicotinic receptor, [3H]pirenzepine binding to the muscarinic M1 receptor, or in choline acetyltransferase activity. These findings provide support for the hypothesis that cholinergic activity is an important neural correlate if consciousness and suggest a mechanism of DOC in DLB involving alterations in the nicotinic receptor, composed of predominantly α4 and β2 subunits. (shrink)